Analysis of a T cell receptor gene as a target of the somatic hypermutation mechanism.

doi:10.1084/jem.176.1.225

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Article

Analysis of a T cell receptor gene as a target of the somatic hypermutation mechanism.

The Journal of experimental medicine - 1 Jul 1992

Hackett J, Stebbins C, Rogerson B, Davis M M, Storb U

Abstract excerpt

In an effort to identify cis-acting elements required for targeting of the somatic hypermutation process in mice, we examined whether a T cell receptor (TCR) transgene under the control of the immunoglobulin (Ig) heavy (H) chain intron enhancer would be mutated in antigen-stimulated B cells. Hybr...

Topics

Animals
Base Sequence
Enhancer Elements, Genetic
Genes, Immunoglobulin
Immunoglobulin Heavy Chains
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Transgenic
Molecular Sequence Data
Mutation
Receptors, Antigen, T-Cell

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