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Article

Analysis of a T cell receptor gene as a target of the somatic hypermutation mechanism.

The Journal of experimental medicine - 1 Jul 1992

Hackett J, Stebbins C, Rogerson B, Davis M M, Storb U

Abstract excerpt

In an effort to identify cis-acting elements required for targeting of the somatic hypermutation process in mice, we examined whether a T cell receptor (TCR) transgene under the control of the immunoglobulin (Ig) heavy (H) chain intron enhancer would be mutated in antigen-stimulated B cells. Hybridomas were established from splenic B cells of mice carrying two copies of the TCR transgene after hyperimmunization...

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Identifiers

PMID: 1613457
DOI: 10.1084/jem.176.1.225
PMCID: PMC2119303

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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