Article
PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jan 1999
Tezuka T, Umemori H, Akiyama T, Nakanishi S, Yamamoto T
Abstract excerpt
Fyn, a member of the Src-family protein-tyrosine kinase (PTK), is implicated in learning and memory that involves N-methyl-D-aspartate (NMDA) receptor function. In this study, we examined how Fyn participates in synaptic plasticity by analyzing the physical and functional interaction between Fyn...
Topics
- Animals
- Cell Line
- Disks Large Homolog 4 Protein
- Guanylate Kinases
- Humans
- Intracellular Signaling Peptides and Proteins
- Membrane Proteins
- Mice
- Mice, Knockout
- Mutation
- N-Methylaspartate