Article
Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor.
The Journal of biological chemistry - 5 Jan 2001
Nakazawa T, Komai S, Tezuka T, Hisatsune C, Umemori H, Semba K, Mishina M, Manabe T, Yamamoto T
Abstract excerpt
The N-methyl-d-aspartate (NMDA) receptors play critical roles in synaptic plasticity, neuronal development, and excitotoxicity. Tyrosine phosphorylation of NMDA receptors by Src-family tyrosine kinases such as Fyn is implicated in synaptic plasticity. To precisely address the roles of NMDA receptor tyrosine phosphorylation, we identified Fyn-mediated phosphorylation sites on the GluR epsilon 2 (NR2B) subunit of...
Topics
- Animals
- Antibodies
- Brain
- Cell Line
- Fibroblasts
- Humans
- Kidney
- Long-Term Potentiation
- Mice
- Mutation
- Neuronal Plasticity
- Peptide Mapping
- Phosphopeptides
- Phosphorylation