Article

Blocking Src-PSD-95 interaction rescues glutamatergic signaling dysregulation in schizophrenia

2024-03-08

Abstract excerpt

The complex and heterogeneous genetic architecture of schizophrenia inspires us to look beyond individual risk genes for therapeutic strategies and target their interactive dynamics and convergence. Postsynaptic NMDA receptor (NMDAR) complexes are a site of such convergence. Src kinase is a molecular hub of NMDAR function, and its protein interaction subnetwork is enriched for risk-genes and altered protein associ...

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Literature Corpus work: 1f78c7bb-f740-5e95-9a7e-49cc928e5ea8
DOI: 10.1101/2024.03.08.584132

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