Article
Activity-dependent NMDA receptor degradation mediated by retrotranslocation and ubiquitination.
Proceedings of the National Academy of Sciences of the United States of America - 12 Apr 2005
Kato Akihiko, Rouach Nathalie, Nicoll Roger A, Bredt David S
Abstract excerpt
The extracellular N-terminal domain (NTD) is the largest region of NMDA receptors; however, biological roles for this ectodomain remain unknown. Here, we determined that the F-box protein, Fbx2, bound to high-mannose glycans of the NR1 ectodomain. F-box proteins specify ubiquitination by linking protein substrates to the terminal E3 ligase. Indeed, ubiquitination of NR1 was increased by Fbx2 and diminished by an...
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