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Article

Increased tyrosine phosphorylation of PSD-95 by Src family kinases after brain ischaemia.

The Biochemical journal - 1 Jan 2009

Du Cai-Ping, Gao Jin, Tai Jian-Min, Liu Yong, Qi Jing, Wang Wei, Hou Xiao-Yu

Abstract excerpt

PSD (postsynaptic density)-95, a scaffold protein that tethers NMDA (N-methyl-D-aspartate) receptors to signal molecules, is implicated in pathological events resulting from excitotoxicity. The present study demonstrates that brain ischaemia and reperfusion increase the tyrosine phosphorylation of PSD-95 in the rat hippocampus. PP2, a specific inhibitor of SrcPTKs (Src family protein tyrosine kinases), prevents...

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Source

Identifiers

PMID: 18721130
DOI: 10.1042/BJ20080004

Genes

PSD

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Increased tyrosine phosphorylation of PSD-95 by Src family kinases after brain ischaemia.PMID 18721130Read ↗

Blocking Src-PSD-95 interaction rescues glutamatergic signaling dysregulation in schizophreniaSemantic proximity Read ↗

PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A.Semantic proximity Read ↗

A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity.Semantic proximity Read ↗

Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor.Semantic proximity Read ↗

Tyrosine Phosphorylation of the Kv2.1 Channel Contributes to Injury in Brain Ischemia.Semantic proximity Read ↗

Regulation of Pro-Apoptotic Phosphorylation of Kv2.1 K+ Channels.Semantic proximity Read ↗

Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors.Semantic proximity Read ↗

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