Article
NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity.
The EMBO journal - 21 Jun 2006
Nakazawa Takanobu, Komai Shoji, Watabe Ayako M, Kiyama Yuji, Fukaya Masahiro, Arima-Yoshida Fumiko, Horai Reiko, Sudo Katsuko, Ebine Kazumi, Delawary Mina, Goto June, Umemori Hisashi, Tezuka Tohru, Iwakura Yoichiro, Watanabe Masahiko, Yamamoto Tadashi, Manabe Toshiya
Abstract excerpt
Phosphorylation of neural proteins in response to a diverse array of external stimuli is one of the main mechanisms underlying dynamic changes in neural circuitry. The NR2B subunit of the NMDA receptor is tyrosine-phosphorylated in the brain, with Tyr-1472 its major phosphorylation site. Here, we generate mice with a knockin mutation of the Tyr-1472 site to phenylalanine (Y1472F) and show that Tyr-1472...
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