Article
Postsynaptic density 95 (PSD-95) serine 561 phosphorylation regulates a conformational switch and bidirectional dendritic spine structural plasticity.
The Journal of biological chemistry - 29 Sept 2017
Wu Qian, Sun Miao, Bernard Laura P, Zhang Huaye
Abstract excerpt
Postsynaptic density 95 (PSD-95) is a major synaptic scaffolding protein that plays a key role in bidirectional synaptic plasticity, which is a process important for learning and memory. It is known that PSD-95 shows increased dynamics upon induction of plasticity. However, the underlying structural and functional changes in PSD-95 that mediate its role in plasticity remain unclear. Here we show that...
Topics
- Amino Acid Substitution
- Animals
- Cells, Cultured
- Dendrites
- Disks Large Homolog 4 Protein
- Embryo, Mammalian
- Hippocampus
- Intracellular Signaling Peptides and Proteins
- Membrane Proteins
- Models, Molecular
- Mutation
- Nerve Tissue Proteins
- Neuronal Plasticity