Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fyn-mediated phosphorylation of Pyk2 promotes its activation and dissociation downstream of gonadotropin-releasing hormone receptor.

The FEBS journal - 1 Aug 2020

Higa-Nakamine Sayomi, Okitsu-Sakurayama Shiho, Kina Shinichiro, Yamamoto Hideyuki

Abstract excerpt

The receptor for gonadotropin-releasing hormone (GnRH) is highly expressed in hypothalamic GnRH neurons, as well as in anterior pituitary gonadotrophs. In our previous study, we found that stimulation of the GnRH receptor activated protein kinase D1 (PKD1), and PKD1 was involved in the Fyn-mediated activation of proline-rich tyrosine kinase 2 (Pyk2) in cultured GnRH neurons (GT1-7 cells). In the present study, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dasatinib
Share to Focal Adhesion Kinase 2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gonadotropin-Releasing Hormone

Share to Piperazines

Share to Proto-Oncogene Proteins c-fyn

Share to Pyridazines

Share to Receptors, LHRH

Share to Tyrosine

Source

Identifiers

PMID: 31994829
DOI: 10.1111/febs.15231

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fyn-mediated phosphorylation of Pyk2 promotes its activation and dissociation downstream of gonadotropin-releasing hormone receptor.PMID 31994829Read ↗

Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor.Semantic proximity Read ↗

PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A.Semantic proximity Read ↗

Ganglioside GQ1b induces dopamine release through the activation of Pyk2.Semantic proximity Read ↗

A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1.Semantic proximity Read ↗

The aspartic acid of Fyn at 390 is critical for neuronal migration during corticogenesis.Semantic proximity Read ↗

Mechanisms of GnRH-induced extracellular signal-regulated kinase nuclear localization.Semantic proximity Read ↗

The phosphorylation site T613 in the β-subunit of rat epithelial Na+ channel (ENaC) modulates channel inhibition by Nedd4-2.Semantic proximity Read ↗

Selective involvement of p130Cas/Crk/Pyk2/c-Src in endothelin-1-induced JNK activation.Semantic proximity Read ↗

Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32.Semantic proximity Read ↗

Sequential protein kinase C (PKC)-dependent and PKC-independent protein kinase D catalytic activation via Gq-coupled receptors: differential regulation of activation loop Ser(744) and Ser(748) phosphorylation.Semantic proximity Read ↗

The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism for feedback inhibition.Semantic proximity Read ↗

Stimulation of mitogen-activated protein kinase by gonadotropin-releasing hormone: evidence for the involvement of protein kinase C.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.