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Article

Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression.

Neuron - 30 Oct 2003

Colledge Marcie, Snyder Eric M, Crozier Robert A, Soderling Jacquelyn A, Jin Yetao, Langeberg Lorene K, Lu Hua, Bear Mark F, Scott John D

Abstract excerpt

PSD-95 is a major scaffolding protein of the postsynaptic density, tethering NMDA- and AMPA-type glutamate receptors to signaling proteins and the neuronal cytoskeleton. Here we show that PSD-95 is regulated by the ubiquitin-proteasome pathway. PSD-95 interacts with and is ubiquitinated by the E3 ligase Mdm2. In response to NMDA receptor activation, PSD-95 is ubiquitinated and rapidly removed from synaptic sites...

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Source

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Identifiers

PMID: 14642282
DOI: 10.1016/s0896-6273(03)00687-1
PMCID: PMC3963808

Genes

PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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