Article
The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1.
Neuron - 13 Nov 2003
Krapivinsky Grigory, Krapivinsky Luba, Manasian Yunona, Ivanov Anton, Tyzio Roman, Pellegrino Christophe, Ben-Ari Yehezkel, Clapham David E, Medina Igor
Abstract excerpt
The NMDA subtype of glutamate receptors (NMDAR) at excitatory neuronal synapses plays a key role in synaptic plasticity. The extracellular signal-regulated kinase (ERK1,2 or ERK) pathway is an essential component of NMDAR signal transduction controlling the neuroplasticity underlying memory processes, neuronal development, and refinement of synaptic connections. Here we show that NR2B, but not NR2A or NR1...
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