Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model.

Nature communications - 30 May 2017

Giralt Albert, Brito Veronica, Chevy Quentin, Simonnet Clémence, Otsu Yo, Cifuentes-Díaz Carmen, de Pins Benoit, Coura Renata, Alberch Jordi, Ginés Sílvia, Poncer Jean-Christophe, Girault Jean-Antoine

Abstract excerpt

The structure and function of spines and excitatory synapses are under the dynamic control of multiple signalling networks. Although tyrosine phosphorylation is involved, its regulation and importance are not well understood. Here we study the role of Pyk2, a non-receptor calcium-dependent protein-tyrosine kinase highly expressed in the hippocampus. Hippocampal-related learning and CA1 long-term potentiation are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cognition Disorders
Share to Dendritic Spines

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Excitatory Postsynaptic Potentials

Share to Focal Adhesion Kinase 2

Share to Huntington Disease

Share to Long-Term Potentiation

Share to Receptors, N-Methyl-D-Aspartate

Share to Synapses

Source

Open in PubMed Open full text

Identifiers

PMID: 28555636
DOI: 10.1038/ncomms15592
PMCID: PMC5459995

Genes

PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model.PMID 28555636Read ↗

Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and LossSemantic proximity Read ↗

PYK2 in the dorsal striatum of Huntington’s disease R6/2 mouse modelSemantic proximity Read ↗

Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy.Semantic proximity Read ↗

HIPK2 in the physiology of nervous system and its implications in neurological disordersSemantic proximity Read ↗

Pyk2 is a Novel Tau Tyrosine Kinase that is Regulated by the Tyrosine Kinase Fyn.Semantic proximity Read ↗

Revealing Notch-dependencies in synaptic targets associated with Alzheimer’s diseaseSemantic proximity Read ↗

Casein kinase 2 phosphorylation of protein kinase C and casein kinase 2 substrate in neurons (PACSIN) 1 protein regulates neuronal spine formation.Semantic proximity Read ↗

KIBRA-PKCγ signaling pathway modulates memory performance in mice and humansSemantic proximity Read ↗

PP1β opposes classic PP1 function, inhibiting spine maturation and promoting LTPSemantic proximity Read ↗

NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity.Semantic proximity Read ↗

MAP2 is Differentially Phosphorylated in Schizophrenia, Altering its FunctionSemantic proximity Read ↗

PTK2B/Pyk2 overexpression improves a mouse model of Alzheimer's diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.