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Article

Functional characterization of Dictyostelium discoideum mutant myosins equivalent to human familial hypertrophic cardiomyopathy.

Advances in experimental medicine and biology - 1 Jan 1998

Fujita H, Sugiura S, Momomura S, Sugi H, Sutoh K

Abstract excerpt

Familial hypertrophic cardiomyopathy (FHC) is caused by missence mutations in beta-myosin heavy chain or other various sarcomeric proteins. To elucidate the functional impact of FHC mutations in myosin heavy chain, we generated Dictyostelium discoideum myosin II mutants equivalent to human FHC mutations by site-directed mutagenesis, and characterized their molecular-basis motor function. The current mutants, i.e....

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PMID: 9889823
DOI: 10.1007/978-1-4684-6039-1_16

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