Functional characterization of Dictyostelium discoideum mutant myosins equivalent to human familial hypertrophic cardiomyopathy.

doi:10.1007/978-1-4684-6039-1_16

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Article

Functional characterization of Dictyostelium discoideum mutant myosins equivalent to human familial hypertrophic cardiomyopathy.

Advances in experimental medicine and biology - 1 Jan 1998

Fujita H, Sugiura S, Momomura S, Sugi H, Sutoh K

Abstract excerpt

Familial hypertrophic cardiomyopathy (FHC) is caused by missence mutations in beta-myosin heavy chain or other various sarcomeric proteins. To elucidate the functional impact of FHC mutations in myosin heavy chain, we generated Dictyostelium discoideum myosin II mutants equivalent to human FHC mu...

Topics

Amino Acid Sequence
Animals
Cardiomyopathy, Hypertrophic
Dictyostelium
Humans
Molecular Sequence Data
Mutation
Myocardial Contraction
Myosins
Protein Conformation
Recombinant Proteins

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