Article
Biological, biochemical, and kinetic effects of mutations of the cardiomyopathy loop of Dictyostelium myosin II: importance of ALA400.
The Journal of biological chemistry - 22 Jul 2005
Liu Xiong, Shu Shi, Kovács Mihály, Korn Edward D
Abstract excerpt
The cardiomyopathy (CM)-loop of the heavy chain of class-II myosins begins with a highly conserved Arg residue (whose mutation in human beta-cardiac myosin II results in familial hypertrophic cardiomyopathy). The CM-loop of Dictyostelium myosin II (Arg397-Gln407) is essential for its biological functions and biochemical activities. We found that the CM-loop of smooth muscle myosin II substituted partially, and...
Topics
- Actins
- Adenosine Diphosphate
- Adenosine Triphosphate
- Alanine
- Amino Acid Sequence
- Amino Acid Substitution
- Animals
- Cardiomyopathy, Hypertrophic, Familial
- Dictyostelium
- Humans
- Kinetics
- Mutation
- Myosin Type II
- Phosphates
- Recombinant Fusion Proteins