Article
Structure-function studies of the myosin motor domain: importance of the 50-kDa cleft.
Molecular biology of the cell - 1 Jul 1996
Ruppel K M, Spudich J A
Abstract excerpt
We used random mutagenesis to create 21 point mutations in a highly conserved region of the motor domain of Dictyostelium myosin and classified them into three distinct groups based on the ability to complement myosin null cell phenotypes: wild type, intermediate, and null. Biochemical analysis of the mutated myosins also revealed three classes of mutants that correlated well with the phenotypic classification....
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