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Article

Impact of familial hypertrophic cardiomyopathy-linked mutations in the NH2 terminus of the RLC on β-myosin cross-bridge mechanics.

Journal of applied physiology (Bethesda, Md. : 1985) - 15 Dec 2014

Farman Gerrie P, Muthu Priya, Kazmierczak Katarzyna, Szczesna-Cordary Danuta, Moore Jeffrey R

Abstract excerpt

Familial hypertrophic cardiomyopathy (HCM) is associated with mutations in sarcomeric proteins, including the myosin regulatory light chain (RLC). Here we studied the impact of three HCM mutations located in the NH2 terminus of the RLC on the molecular mechanism of β-myosin heavy chain (MHC) cross-bridge mechanics using the in vitro motility assay. To generate mutant β-myosin, native RLC was depleted from porcine...

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Share to Cardiac Myosins
Share to Cardiomyopathy, Hypertrophic, Familial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Myocardial Contraction

Share to Myocytes, Cardiac

Share to Myosin Heavy Chains

Share to Myosin Light Chains

Share to Protein Interaction Domains and Motifs

Source

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Identifiers

PMID: 25324513
DOI: 10.1152/japplphysiol.00798.2014
PMCID: PMC4269682

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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