Article
Myosin dilated cardiomyopathy mutation S532P disrupts actomyosin interactions, leading to altered muscle kinetics, reduced locomotion, and cardiac dilation in Drosophila.
Molecular biology of the cell - 19 Aug 2021
Trujillo Adriana S, Hsu Karen H, Puthawala Joy, Viswanathan Meera C, Loya Amy, Irving Thomas C, Cammarato Anthony, Swank Douglas M, Bernstein Sanford I
Abstract excerpt
Dilated cardiomyopathy (DCM), a life-threatening disease characterized by pathological heart enlargement, can be caused by myosin mutations that reduce contractile function. To better define the mechanistic basis of this disease, we employed the powerful genetic and integrative approaches available in Drosophila melanogaster. To this end, we generated and analyzed the first fly model of human myosin-induced DCM....
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