Article
Changes in Mg2+ ion concentration and heavy chain phosphorylation regulate the motor activity of a class I myosin.
The Journal of biological chemistry - 18 Feb 2005
Fujita-Becker Setsuko, Dürrwang Ulrike, Erent Muriel, Clark Richard J, Geeves Michael A, Manstein Dietmar J
Abstract excerpt
Class I myosins are single-headed motor proteins implicated in various motile processes including organelle translocation, ion channel gating, and cytoskeleton reorganization. Dictyostelium discoideum myosin-ID belongs to subclass 1alpha, whose members are thought to be tuned for rapid sliding. The direct analysis of myosin-ID motor activity is made possible by the production of single polypeptide constructs...
Topics
- Actins
- Actomyosin
- Adenosine Diphosphate
- Adenosine Triphosphate
- Amino Acid Sequence
- Animals
- Cations, Divalent
- Dictyostelium
- Kinetics
- Magnesium
- Molecular Motor Proteins
- Movement
- Mutation
- Myosin Heavy Chains