Article
Deficiency of huntingtin has pleiotropic effects in the social amoeba Dictyostelium discoideum.
PLoS genetics - 1 Apr 2011
Myre Michael A, Lumsden Amanda L, Thompson Morgan N, Wasco Wilma, MacDonald Marcy E, Gusella James F
Abstract excerpt
Huntingtin is a large HEAT repeat protein first identified in humans, where a polyglutamine tract expansion near the amino terminus causes a gain-of-function mechanism that leads to selective neuronal loss in Huntington's disease (HD). Genetic evidence in humans and knock-in mouse models suggests that this gain-of-function involves an increase or deregulation of some aspect of huntingtin's normal function(s),...
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