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Article

Paired-related homeobox genes cooperate in handplate and hindlimb zeugopod morphogenesis.

Developmental biology - 1 Jan 1999

Lu M F, Cheng H T, Lacy A R, Kern M J, Argao E A, Potter S S, Olson E N, Martin J F

Abstract excerpt

The closely related homeobox genes prx-1 and prx-2 are expressed in lateral plate and limb bud mesoderm, but targeted inactivation of these genes failed to demonstrate a limb phenotype. Here we report that mice carrying compound mutations in prx-1 and prx-2 have severe limb deformities. In the forelimb autopod, pre- and postaxial polydactyly were found most commonly, but also syndactyly, oligodactyly, and...

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Source

Identifiers

PMID: 9882503
DOI: 10.1006/dbio.1998.9116

Genes

BMP4
FGF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Paired-related homeobox genes cooperate in handplate and hindlimb zeugopod morphogenesis.PMID 9882503Read ↗

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Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation.Semantic proximity Read ↗

Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression.Semantic proximity Read ↗

prx-1 functions cooperatively with another paired-related homeobox gene, prx-2, to maintain cell fates within the craniofacial mesenchyme.Semantic proximity Read ↗

Analysis of Msx1; Msx2 double mutants reveals multiple roles for Msx genes in limb development.Semantic proximity Read ↗

The Hemimelic extra toes mouse mutant: Historical perspective on unraveling mechanisms of dysmorphogenesis.Semantic proximity Read ↗

Defective Hand1 phosphoregulation uncovers essential roles for Hand1 in limb morphogenesis.Semantic proximity Read ↗

Mox2 is a component of the genetic hierarchy controlling limb muscle development.Semantic proximity Read ↗

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Genetics of Limb Development and Congenital Hand MalformationsSemantic proximity Read ↗

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