Article
Paired-related homeobox genes cooperate in handplate and hindlimb zeugopod morphogenesis.
Developmental biology - 1 Jan 1999
Lu M F, Cheng H T, Lacy A R, Kern M J, Argao E A, Potter S S, Olson E N, Martin J F
Abstract excerpt
The closely related homeobox genes prx-1 and prx-2 are expressed in lateral plate and limb bud mesoderm, but targeted inactivation of these genes failed to demonstrate a limb phenotype. Here we report that mice carrying compound mutations in prx-1 and prx-2 have severe limb deformities. In the fo...
Topics
- Animals
- DNA-Binding Proteins
- Embryonic and Fetal Development
- Forelimb
- Gene Expression Regulation, Developmental
- Genotype
- Hindlimb
- Homeodomain Proteins
- Limb Buds
- MSX1 Transcription Factor
- Mesoderm
- Mice
- Mice, Knockout
- Morphogenesis
- Transcription Factors