Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mox2 is a component of the genetic hierarchy controlling limb muscle development.

Nature - 1 Jul 1999

Mankoo B S, Collins N S, Ashby P, Grigorieva E, Pevny L H, Candia A, Wright C V, Rigby P W, Pachnis V

Abstract excerpt

The skeletal muscles of the limbs develop from myogenic progenitors that originate in the paraxial mesoderm and migrate into the limb-bud mesenchyme. Among the genes known to be important for muscle development in mammalian embryos are those encoding the basic helix-loop-helix (bHLH) myogenic regulatory factors (MRFs; MyoD, Myf5, myogenin and MRF4) and Pax3, a paired-type homeobox gene that is critical for the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Surface
Share to Embryonic and Fetal Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extremities

Share to Gene Targeting

Share to Genes, Homeobox

Share to Mesoderm

Share to Morphogenesis

Share to Myogenin

Source

Identifiers

PMID: 10403250
DOI: 10.1038/21892

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mox2 is a component of the genetic hierarchy controlling limb muscle development.PMID 10403250Read ↗

The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites.Semantic proximity Read ↗

Analysis of Msx1; Msx2 double mutants reveals multiple roles for Msx genes in limb development.Semantic proximity Read ↗

BMP-mediated functional cooperation between Dlx5;Dlx6 and Msx1;Msx2 during mammalian limb development.Semantic proximity Read ↗

Barx homeobox family in muscle development and regeneration.Semantic proximity Read ↗

Barx2 is expressed in satellite cells and is required for normal muscle growth and regeneration.Semantic proximity Read ↗

POU homeodomain genes and myogenesis.Semantic proximity Read ↗

Lbx1 is required for muscle precursor migration along a lateral pathway into the limb.Semantic proximity Read ↗

Paired-related homeobox genes cooperate in handplate and hindlimb zeugopod morphogenesis.Semantic proximity Read ↗

Tbx2 terminates shh/fgf signaling in the developing mouse limb bud by direct repression of gremlin1.Semantic proximity Read ↗

A novel genetic hierarchy functions during hypaxial myogenesis: Pax3 directly activates Myf5 in muscle progenitor cells in the limb.Semantic proximity Read ↗

Altered myogenesis in Six1-deficient mice.Semantic proximity Read ↗

Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.