Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression.

Development (Cambridge, England) - 1 Jun 2006

Capellini Terence D, Di Giacomo Giuseppina, Salsi Valentina, Brendolan Andrea, Ferretti Elisabetta, Srivastava Deepak, Zappavigna Vincenzo, Selleri Licia

Abstract excerpt

Vertebrate limb development occurs along three cardinal axes-proximodistal, anteroposterior and dorsoventral-that are established via the organization of signaling centers, such as the zone of polarizing activity (ZPA). Distal limb development, in turn, requires a molecular feedback loop between the ZPA expression of sonic hedgehog (Shh) and the apical ectodermal ridge. The TALE homeoprotein Pbx1 has been shown...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Transcription Factors
Share to Body Patterning

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Extremities

Share to Gene Expression Regulation, Developmental

Share to Hedgehog Proteins

Share to Homeodomain Proteins

Share to Proto-Oncogene Proteins

Share to Trans-Activators

Source

Identifiers

PMID: 16672333
DOI: 10.1242/dev.02395

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression.PMID 16672333Read ↗

Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome.Semantic proximity Read ↗

Anteroposterior patterning in the limb and digit specification: contribution of mouse genetics.Semantic proximity Read ↗

Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation.Semantic proximity Read ↗

Some distal limb structures develop in mice lacking Sonic hedgehog signaling.Semantic proximity Read ↗

Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development.Semantic proximity Read ↗

Defective Hand1 phosphoregulation uncovers essential roles for Hand1 in limb morphogenesis.Semantic proximity Read ↗

The Conserved Sonic Hedgehog Limb Enhancer Consists of Discrete Functional Elements that Regulate Precise Spatial Expression.Semantic proximity Read ↗

Progression of vertebrate limb development through SHH-mediated counteraction of GLI3.Semantic proximity Read ↗

Pbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundaries.Semantic proximity Read ↗

Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development.Semantic proximity Read ↗

Paired-related homeobox genes cooperate in handplate and hindlimb zeugopod morphogenesis.Semantic proximity Read ↗

A duplicated zone of polarizing activity in polydactylous mouse mutants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.