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Article

Analysis of Msx1; Msx2 double mutants reveals multiple roles for Msx genes in limb development.

Development (Cambridge, England) - 1 Jul 2005

Lallemand Yvan, Nicola Marie-Anne, Ramos Casto, Bach Antoine, Cloment Cécile Saint, Robert Benoît

Abstract excerpt

The homeobox-containing genes Msx1 and Msx2 are highly expressed in the limb field from the earliest stages of limb formation and, subsequently, in both the apical ectodermal ridge and underlying mesenchyme. However, mice homozygous for a null mutation in either Msx1 or Msx2 do not display abnormalities in limb development. By contrast, Msx1; Msx2 double mutants exhibit a severe limb phenotype. Our analysis...

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Identifiers

PMID: 15930102
DOI: 10.1242/dev.01877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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