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Article

Defective Hand1 phosphoregulation uncovers essential roles for Hand1 in limb morphogenesis.

Development (Cambridge, England) - 1 Jul 2017

Firulli Beth A, Milliar Hannah, Toolan Kevin P, Harkin Jade, Fuchs Robyn K, Robling Alex G, Firulli Anthony B

Abstract excerpt

The morphogenesis of the vertebrate limbs is a complex process in which cell signaling and transcriptional regulation coordinate diverse structural adaptations in diverse species. In this study, we examine the consequences of altering Hand1 dimer choice regulation within developing vertebrate limbs. Although Hand1 deletion via the limb-specific Prrx1-Cre reveals a non-essential role for Hand1 in mouse limb...

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Identifiers

PMID: 28576769
DOI: 10.1242/dev.149963
PMCID: PMC5536869

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