Article
Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbs.
Development (Cambridge, England) - 1 Oct 1998
ten Berge D, Brouwer A, Korving J, Martin J F, Meijlink F
Abstract excerpt
Prx1 and Prx2 are closely related paired-class homeobox genes that are expressed in very similar patterns predominantly in mesenchyme. Prx1 loss-of-function mutants show skeletal defects in skull, limbs and vertebral column (Martin, J. F., Bradley, A. and Olson, E. N. (1995) Genes Dev. 9, 1237-12...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Bone Development
- Cloning, Molecular
- Craniofacial Abnormalities
- DNA Primers
- DNA, Complementary
- Ear, Inner
- Extremities
- Facial Bones
- Genes, Homeobox
- Homeodomain Proteins
- Limb Deformities, Congenital
- Mice
- Mice, Knockout
- Molecular Sequence Data
- Phenotype