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Article

Multiple molecular pathways for fitness recovery of an RNA virus debilitated by operation of Muller's ratchet.

Journal of molecular biology - 15 Jan 1999

Escarmís C, Dávila M, Domingo E

Abstract excerpt

Repeated bottleneck passages of RNA viruses result in fitness losses due to accumulation of deleterious mutations. We have analysed the molecular events underlying fitness recovery of a highly debilitated foot- and-mouth disease virus (FMDV) clone, upon serial passage in BHK-21 cells. The debilitated clone included an unusual, internal polyadenylate extension preceding the second functional AUG initiation codon,...

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Identifiers

PMID: 9878424
DOI: 10.1006/jmbi.1998.2366

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