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Article

Involvement of a joker mutation in a polymerase-independent lethal mutagenesis escape mechanism.

Virology - 1 Jul 2016

Agudo Rubén, de la Higuera Ignacio, Arias Armando, Grande-Pérez Ana, Domingo Esteban

Abstract excerpt

We previously characterized a foot-and-mouth disease virus (FMDV) with three amino acid replacements in its polymerase (3D) that conferred resistance to the mutagenic nucleoside analogue ribavirin. Here we show that passage of this mutant in the presence of high ribavirin concentrations resulted in selection of viruses with the additional replacement I248T in 2C. This 2C substitution alone (even in the absence of...

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Source

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Identifiers

PMID: 27136067
DOI: 10.1016/j.virol.2016.04.023
PMCID: PMC7111656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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