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Article

Subclonal components of consensus fitness in an RNA virus clone.

Journal of virology - 1 Jul 1994

Duarte E A, Novella I S, Ledesma S, Clarke D K, Moya A, Elena S F, Domingo E, Holland J J

Abstract excerpt

Most RNA virus populations exhibit extremely high mutation frequencies which generate complex, genetically heterogeneous populations referred to as quasi-species. Previous work has shown that when a large spectrum of the quasi-species is transferred, natural selection operates, leading to elimination of noncompetitive (inferior) genomes and rapid gains in fitness. However, whenever the population is repeatedly...

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Identifiers

PMID: 8207804
DOI: 10.1128/JVI.68.7.4295-4301.1994
PMCID: PMC236352

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