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Article

Subclonal components of consensus fitness in an RNA virus clone.

Journal of virology - 1 Jul 1994

Duarte E A, Novella I S, Ledesma S, Clarke D K, Moya A, Elena S F, Domingo E, Holland J J

Abstract excerpt

Most RNA virus populations exhibit extremely high mutation frequencies which generate complex, genetically heterogeneous populations referred to as quasi-species. Previous work has shown that when a large spectrum of the quasi-species is transferred, natural selection operates, leading to elimination of noncompetitive (inferior) genomes and rapid gains in fitness. However, whenever the population is repeatedly...

Topics

Animals
Cells, Cultured
Cricetinae
Genes, Viral
Mutation
Vesicular stomatitis Indiana virus
Virus Replication

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 8207804
DOI: 10.1128/JVI.68.7.4295-4301.1994
PMCID: PMC236352

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8207804-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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