Article
Foot-and-mouth disease virus evolution: exploring pathways towards virus extinction.
Current topics in microbiology and immunology - 1 Jan 2005
Domingo E, Pariente N, Airaksinen A, Gonzaĺez-Lopez C, Sierra S, Herrera M, Grande-Pérez A, Lowenstein P R, Manrubia S C, Lázaro E, Escarmís C
Abstract excerpt
Foot-and-mouth disease virus (FMDV) is genetically and phenotypically variable. As a typical RNA virus, FMDV follows a quasispecies dynamics, with the many biological implications of such a dynamics. Mutant spectra provide a reservoir of FMDV variants, and minority subpopulations may become dominant in response to environmental demands or as a result of statistical fluctuations in population size. Accumulation of...
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