Genetic lesions associated with Muller's ratchet in an RNA virus.

doi:10.1006/jmbi.1996.0639

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Article

Genetic lesions associated with Muller's ratchet in an RNA virus.

Journal of molecular biology - 29 Nov 1996

Escarmís C, Dávila M, Charpentier N, Bracho A, Moya A, Domingo E

Abstract excerpt

The molecular basis of Muller's ratchet has been investigated using the important animal pathogen foot-and-mouth disease virus (FMDV). Clones from two FMDV populations were subjected to serial plaque transfers (repeated bottleneck events) on host BHK-21 cells. Relative fitness losses were documen...

Topics

Animals
Aphthovirus
Cell Line
Cricetinae
Extinction, Psychological
Mutation
Nucleic Acid Conformation
RNA, Viral
Viral Plaque Assay

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