Article
Quasispecies dynamics and RNA virus extinction.
Virus research - 1 Feb 2005
Domingo Esteban, Escarmís Cristina, Lázaro Ester, Manrubia Susanna C
Abstract excerpt
The extinction of foot-and-mouth disease virus (FMDV) is strongly influenced by mutation rates, types of mutations, relative viral fitness and virus population regimens during infection. Here we review experimental results and theoretical models that describe a contrast between the effective extinction of FMDV subjected to increased mutagenesis, and the remarkable resistance to extinction of the same and related...
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