Molecular modelling investigation of wild-type and the R528H mutated segment IIS4 of human L-type voltage-gated calcium channels.

doi:10.1093/protein/11.11.1033

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Article

Molecular modelling investigation of wild-type and the R528H mutated segment IIS4 of human L-type voltage-gated calcium channels.

Protein engineering - 1 Nov 1998

Schleifer K J, Höltje H D

Abstract excerpt

A molecular modelling study was performed in order to investigate the pathologically modified properties of L-type voltage-gated calcium channels caused by the arginine-to-histidine mutation at position 528 (R528H) in segment IIS4. For an appropriate consideration of the ionization state the fini...

Topics

Amino Acid Sequence
Animals
Calcium Channels
Calcium Channels, L-Type
Humans
Hydrogen Bonding
Ion Channel Gating
Models, Molecular
Molecular Sequence Data
Mutation
Sequence Homology, Amino Acid
Static Electricity

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