Article
Mechanisms Responsible for ω-Pore Currents in Cav Calcium Channel Voltage-Sensing Domains.
Biophysical journal - 3 Oct 2017
Monteleone Stefania, Lieb Andreas, Pinggera Alexandra, Negro Giulia, Fuchs Julian E, Hofer Florian, Striessnig Jörg, Tuluc Petronel, Liedl Klaus R
Abstract excerpt
Mutations of positively charged amino acids in the S4 transmembrane segment of a voltage-gated ion channel form ion-conducting pathways through the voltage-sensing domain, named ω-current. Here, we used structure modeling and MD simulations to predict pathogenic ω-currents in CaV1.1 and CaV1.3 Ca2+ channels bearing several S4 charge mutations. Our modeling predicts that mutations of CaV1.1-R1 (R528H/G, R897S) or...
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