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Article

Functional interaction between S1 and S4 segments in voltage-gated sodium channels revealed by human channelopathies.

Channels (Austin, Tex.) - 1 Jan 2014

Amarouch Mohamed-Yassine, Kasimova Marina A, Tarek Mounir, Abriel Hugues

Abstract excerpt

The p.I141V mutation of the voltage-gated sodium channel is associated with several clinical hyper-excitability phenotypes. To understand the structural bases of the p.I141V biophysical alterations, molecular dynamics simulations were performed. These simulations predicted that the p.I141V substitution induces the formation of a hydrogen bond between the Y168 residue of the S2 segment and the R225 residue of the...

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Identifiers

PMID: 25483584
DOI: 10.4161/19336950.2014.958922
PMCID: PMC4594541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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