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Article

Structural determinants of L-type channel activation in segment IIS6 revealed by a retinal disorder.

The Journal of biological chemistry - 18 Nov 2005

Hohaus Annette, Beyl Stanislav, Kudrnac Michaela, Berjukow Stanislav, Timin Eugen N, Marksteiner Rainer, Maw Marion A, Hering Steffen

Abstract excerpt

The mechanism of channel opening for voltage-gated calcium channels is poorly understood. The importance of a conserved isoleucine residue in the pore-lining segment IIS6 has recently been highlighted by functional analyses of a mutation (I745T) in the Ca(V)1.4 channel causing severe visual impairment (Hemara-Wahanui, A., Berjukow, S., Hope, C. I., Dearden, P. K., Wu, S. B., Wilson-Wheeler, J., Sharp, D. M.,...

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Identifiers

PMID: 16157588
DOI: 10.1074/jbc.M507013200
PMCID: PMC3189691

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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