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Article

Integrative Study of the Structural and Dynamical Properties of a KirBac3.1 Mutant: Functional Implication of a Highly Conserved Tryptophan in the Transmembrane Domain.

International journal of molecular sciences - 29 Dec 2021

Fagnen Charline, Bannwarth Ludovic, Oubella Iman, Zuniga Dania, Haouz Ahmed, Forest Eric, Scala Rosa, Bendahhou Saïd, De Zorzi Rita, Perahia David, Vénien-Bryan Catherine

Abstract excerpt

ATP-sensitive potassium (K-ATP) channels are ubiquitously expressed on the plasma membrane of cells in several organs, including the heart, pancreas, and brain, and they govern a wide range of physiological processes. In pancreatic β-cells, K-ATP channels composed of Kir6.2 and SUR1 play a key role in coupling blood glucose and insulin secretion. A tryptophan residue located at the cytosolic end of the...

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Share to Conserved Sequence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Potassium Channels, Inwardly Rectifying

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Identifiers

PMID: 35008764
DOI: 10.3390/ijms23010335
PMCID: PMC8745282

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Integrative Study of the Structural and Dynamical Properties of a KirBac3.1 Mutant: Functional Implication of a Highly Conserved Tryptophan in the Transmembrane Domain.PMID 35008764Read ↗

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