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Article

TrfA dimers play a role in copy-number control of RK2 replication.

Gene - 26 Nov 1998

Toukdarian A E, Helinski D R

Abstract excerpt

Copy-number regulation of the broad-host-range plasmid RK2 is dependent on the plasmid-encoded initiator protein, TrfA, and the RK2 origin of replication. The handcuffing model for copy-number control proposes that TrfA-bound oris reversibly couple to prevent the further initiation of plasmid replication when the copy number in vivo is at or above the replicon-specific copy number. TrfA mutants have been isolated...

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Source

Identifiers

PMID: 9858734
DOI: 10.1016/s0378-1119(98)00370-9

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TrfA dimers play a role in copy-number control of RK2 replication.PMID 9858734Read ↗

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