Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple homeostatic mechanisms in the control of P1 plasmid replication.

Proceedings of the National Academy of Sciences of the United States of America - 22 Feb 2005

Das Nilangshu, Valjavec-Gratian Majda, Basuray Ashish N, Fekete Richard A, Papp Peter P, Paulsson Johan, Chattoraj Dhruba K

Abstract excerpt

Many organisms control initiation of DNA replication by limiting supply or activity of initiator proteins. In plasmids, such as P1, initiators are limited primarily by transcription and dimerization. However, the relevance of initiator limitation to plasmid copy number control has appeared doubtful, because initiator oversupply increases the copy number only marginally. Copy number control instead has been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dimerization
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Helicases

Share to DNA Replication

Share to Gene Dosage

Share to Homeostasis

Share to Plasmids

Share to Trans-Activators

Source

Open in PubMed Open full text

Identifiers

PMID: 15708977
DOI: 10.1073/pnas.0409790102
PMCID: PMC549481

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple homeostatic mechanisms in the control of P1 plasmid replication.PMID 15708977Read ↗

Cooperative binding mode of the inhibitors of R6K replication, pi dimers.Semantic proximity Read ↗

TrfA dimers play a role in copy-number control of RK2 replication.Semantic proximity Read ↗

Multiple pathways of copy control of gamma replicon of R6K: mechanisms both dependent on and independent of cooperativity of interaction of tau protein with DNA affect the copy number.Semantic proximity Read ↗

Relaxation of replication control in chaperone-independent initiator mutants of plasmid P1.Semantic proximity Read ↗

Location of a P1 plasmid replication inhibitor determinant within the initiator gene.Semantic proximity Read ↗

Modulation of ColE1-like plasmid replication for recombinant gene expression.Semantic proximity Read ↗

Control of plasmid replication—How do DNA iterons set the replication frequency?Semantic proximity Read ↗

Dimerization of plasmid DNA accelerates selection for antibiotic resistance.Semantic proximity Read ↗

Copy-up mutants of the plasmid RK2 replication initiation protein are defective in coupling RK2 replication origins.Semantic proximity Read ↗

Estimation of the source-by-source effect of autorepression on genetic noise.Semantic proximity Read ↗

A pot-pourri of plasmid paradoxes: effects of a second copy.Semantic proximity Read ↗

Imaging centromere-based incompatibilities: Insights into the mechanism of incompatibility mediated by low-copy number plasmids.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.