Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The nature of mutations induced by replication–transcription collisions.

Nature - 7 Jul 2016

Sankar T Sabari, Wastuwidyaningtyas Brigitta D, Dong Yuexin, Lewis Sarah A, Wang Jue D

Abstract excerpt

The DNA replication and transcription machineries share a common DNA template and thus can collide with each other co-directionally or head-on. Replication–transcription collisions can cause replication fork arrest, premature transcription termination, DNA breaks, and recombination intermediates threatening genome integrity. Collisions may also trigger mutations, which are major contributors to genetic disease...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine
Share to Bacillus subtilis
Share to Deamination

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to INDEL Mutation

Share to Mutation Rate

Share to Repetitive Sequences, Nucleic Acid

Share to Sigma Factor

Share to Templates, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 27362223
DOI: 10.1038/nature18316
PMCID: PMC4945378

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The nature of mutations induced by replication–transcription collisions.PMID 27362223Read ↗

Encoded errors: mutations and rearrangements mediated by misalignment at repetitive DNA sequences.Semantic proximity Read ↗

DNA replication stress: Causes, resolution and diseaseSemantic proximity Read ↗

Head-on replication-transcription collisions lead to formation of life threatening R-loopsSemantic proximity Read ↗

Oxidative stress drives mutagenesis through transcription coupled repair in bacteriaSemantic proximity Read ↗

DNA Replication-Transcription Conflicts Do Not Significantly Contribute to Spontaneous Mutations Due to Replication Errors in Escherichia coli.Semantic proximity Read ↗

Mechanisms of mutagenesis: DNA replication in the presence of DNA damage.Semantic proximity Read ↗

Roles of DNA polymerases in replication, repair, and recombination in eukaryotes.Semantic proximity Read ↗

DNA replication stress: from molecular mechanisms to human diseaseSemantic proximity Read ↗

How DNA lesions are turned into mutations within cells?Semantic proximity Read ↗

Validation of bacterial replication termination models using simulation of genomic mutations.Semantic proximity Read ↗

Mechanisms of mutagenesis induced by DNA lesions: multiple factors affect mutations in translesion DNA synthesis.Semantic proximity Read ↗

Error-prone DNA polymerases: when making a mistake is the only way to get ahead.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.