Multiple pathways of copy control of gamma replicon of R6K: mechanisms both dependent on and independent of cooperativity of interaction of tau protein with DNA affect the copy number.

doi:10.1073/pnas.91.14.6438

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Article

Multiple pathways of copy control of gamma replicon of R6K: mechanisms both dependent on and independent of cooperativity of interaction of tau protein with DNA affect the copy number.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 1994

Miron A, Patel I, Bastia D

Abstract excerpt

The ability of a replication initiator protein to promote intermolecular pairing of two replication origins resulting in the turning off of the origin pair has been called handcuffing. We have endeavored to test the validity of the handcuffing model by isolating two mutant forms of the tau initia...

Topics

Amino Acid Sequence
Base Sequence
Consensus Sequence
Deoxyribonuclease I
Electrophoresis, Polyacrylamide Gel
Escherichia coli
Genotype
Kinetics
Leucine Zippers
Molecular Sequence Data
Mutagenesis, Site-Directed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligodeoxyribonucleotides

Plasmids

Recombinant Proteins

Replicon

Restriction Mapping

tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 8022801
DOI: 10.1073/pnas.91.14.6438
PMCID: PMC44217

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8022801-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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