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Article

Critical and multiple roles for the CD3epsilon intracytoplasmic tail in double negative to double positive thymocyte differentiation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2009

Brodeur Jean-Francois, Li Samantha, da Silva Martins Maria, Larose Louise, Dave Vibhuti P

Abstract excerpt

The preTCR is associated with signal-transducing CD3gamma, delta, epsilon, and zeta polypeptides. It is generally agreed that CD3 chains play redundant roles in the receptor-mediated signal transduction. In the present study, we show that the intracytoplasmic (IC) domain of CD3epsilon is essential for early thymocyte maturation. We demonstrate that the IC domain-deleted CD3epsilon fails to restore the double...

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Source

Identifiers

PMID: 19342663
DOI: 10.4049/jimmunol.0803679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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