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Article

Preferential requirement of CD3 zeta-mediated signals for development of immature rather than mature thymocytes.

International immunology - 1 Jul 1996

Aoe T, Okamoto Y, Arase H, Ikuta K, Miyazaki J, Ono S, Otuji M, Ohno H, Miyatake S, Saito T

Abstract excerpt

Antigen recognition signals by the TCR are transduced through activation motifs present in the cytoplasmic region of CD3 chains. In vitro analysis has suggested that the CD3zeta chain mediates different signals from other CD3 chains. To analyze the in vivo function of CD3zeta-mediated signals for T cell development, mice expressing a mutant CD3zeta chain lacking all the activation motifs were generated by...

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Identifiers

PMID: 8757951
DOI: 10.1093/intimm/8.7.1055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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