Article
Preferential requirement of CD3 zeta-mediated signals for development of immature rather than mature thymocytes.
International immunology - 1 Jul 1996
Aoe T, Okamoto Y, Arase H, Ikuta K, Miyazaki J, Ono S, Otuji M, Ohno H, Miyatake S, Saito T
Abstract excerpt
Antigen recognition signals by the TCR are transduced through activation motifs present in the cytoplasmic region of CD3 chains. In vitro analysis has suggested that the CD3zeta chain mediates different signals from other CD3 chains. To analyze the in vivo function of CD3zeta-mediated signals for...
Topics
- Animals
- CD3 Complex
- Cell Differentiation
- Flow Cytometry
- Membrane Proteins
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutation
- Receptors, Antigen, T-Cell
- Signal Transduction
- T-Lymphocytes
- Thymus Gland