Article
Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene.
The EMBO journal - 2 Oct 1995
Malissen M, Gillet A, Ardouin L, Bouvier G, Trucy J, Ferrier P, Vivier E, Malissen B
Abstract excerpt
To determine which CD3 components are required for early T cell development, we generated mice with a targeted mutation of the CD3-epsilon gene and characterized their T cell populations relative to those found in CD3-zeta/eta-and recombinase activating gene (RAG)-deficient mice. In the absence of intact CD3-epsilon subunit, thymocytes do not progress beyond the CD44-/lowCD25+ triple-negative stage and appear to...
Topics
- Animals
- Base Sequence
- CD3 Complex
- Cell Differentiation
- Crosses, Genetic
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Gene Targeting
- Homeodomain Proteins
- Hyaluronan Receptors
- Mice
- Mice, Transgenic