Article
Polymorphisms of the T cell receptor CD3delta and CD3epsilon chains affect anti-CD3 antibody binding and T cell activation.
Molecular immunology - 1 Sept 2010
Boding Lasse, Nielsen Martin Weiss, Bonefeld Charlotte Menné, von Essen Marina Rode, Nielsen Bodil Lisbeth, Lauritsen Jens Peter H, Hansen Ann Kathrine, Nielsen Morten Milek, Kongsbak Martin, Rubin Maria, Vennegaard Marie Torp, Odum Niels, Geisler Carsten
Abstract excerpt
T cell receptor (TCR) structure and function have been thoroughly studied for decades. Production and analyses of knock-out and knock-in mice with mutations in the CD3 chains have contributed significantly to these studies. The generation of such gene-modified mice relies on the availability of suitable embryonic stem (ES) cell lines. Traditionally, ES cell lines from the 129 mouse strains have been used followed...
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