Article
Uncoupling of S phase and mitosis in cardiomyocytes and hepatocytes lacking the winged-helix transcription factor Trident.
Current biology : CB - 3 Dec 1998
Korver W, Schilham M W, Moerer P, van den Hoff M J, Dam K, Lamers W H, Medema R H, Clevers H
Abstract excerpt
In order to maintain a stable karyotype, the eukaryotic cell cycle is coordinated such that only one round of S phase precedes each mitosis, and mitosis is not initiated until DNA replication is completed. Several checkpoints and regulatory proteins have been defined in lower eukaryotes that govern this coordination, but little is known about the proteins that are involved in mammalian cells. Previously, we have...
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