Article
Uncoupling of S phase and mitosis in cardiomyocytes and hepatocytes lacking the winged-helix transcription factor Trident.
Current biology : CB - 3 Dec 1998
Korver W, Schilham M W, Moerer P, van den Hoff M J, Dam K, Lamers W H, Medema R H, Clevers H
Abstract excerpt
In order to maintain a stable karyotype, the eukaryotic cell cycle is coordinated such that only one round of S phase precedes each mitosis, and mitosis is not initiated until DNA replication is completed. Several checkpoints and regulatory proteins have been defined in lower eukaryotes that gove...
Topics
- Animals
- Animals, Newborn
- DNA Replication
- Female
- Forkhead Box Protein M1
- Forkhead Transcription Factors
- Gene Expression Regulation, Developmental
- Gestational Age
- Heart
- Liver
- Mice
- Mice, Knockout
- Mitosis
- Myocardium
- Phenotype
- Polyploidy
- Pregnancy
- S Phase