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Article

Defect of mitotic vimentin phosphorylation causes microophthalmia and cataract via aneuploidy and senescence in lens epithelial cells.

The Journal of biological chemistry - 13 Dec 2013

Matsuyama Makoto, Tanaka Hiroki, Inoko Akihito, Goto Hidemasa, Yonemura Shigenobu, Kobori Kyoko, Hayashi Yuko, Kondo Eisaku, Itohara Shigeyoshi, Izawa Ichiro, Inagaki Masaki

Abstract excerpt

Vimentin, a type III intermediate filament (IF) protein, is phosphorylated predominantly in mitosis. The expression of a phosphorylation-compromised vimentin mutant in T24 cultured cells leads to cytokinetic failure, resulting in binucleation (multinucleation). The physiological significance of intermediate filament phosphorylation during mitosis for organogenesis and tissue homeostasis was uncertain. Here, we...

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Identifiers

PMID: 24142690
DOI: 10.1074/jbc.M113.514737
PMCID: PMC3861614

Genes

VIM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Defect of mitotic vimentin phosphorylation causes microophthalmia and cataract via aneuploidy and senescence in lens epithelial cells.PMID 24142690Read ↗

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