Article

Oncogene-induced cardiac neoplasia shares similar mechanisms with heart regeneration in zebrafish

2020-12-15

Abstract excerpt

The human heart is a poorly regenerative organ and cardiac tumors are extremely rare. The zebrafish heart can restore its damaged myocardium through cardiomyocyte proliferation. Whether this endogenous capacity causes a susceptibility to neoplasia remains unknown. Here, we established a strategy to conditionally express the HRAS G12V oncogene in zebrafish cardiomyocytes. The induction of this transgene in larvae...

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Literature Corpus work: 1cd5bacf-614d-59f0-aebf-89257f00ffde
DOI: 10.1101/2020.12.15.422853

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