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Article

Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative Splicing of the Triadin Gene in the Heart

29 Aug 2022

Abstract excerpt

Background: Abnormalities in Ca 2+ homeostasis are associated with cardiac arrhythmias and heart failure. Triadin plays an important role in Ca 2+ homeostasis in cardiomyocytes. Alternative splicing of a single triadin gene produces multiple triadin isoforms. The cardiac-predominant isoform, mouse MT-1 or human Trisk32, is encoded by triadin exons 1 to 8. In humans, mutations in the triadin gene that lead to a...

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PMID: 35862102
DOI: 10.1161/circulationaha.121.058017

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