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Article

Generation of a Triadin KnockOut Syndrome Zebrafish Model.

International journal of molecular sciences - 8 Sept 2021

Vecchi Vanilla Martina, Spreafico Marco, Brix Alessia, Santoni Anna, Sala Simone, Pistocchi Anna, Marozzi Anna, Di Resta Chiara

Abstract excerpt

Different forms of sudden cardiac death have been described, including a recently identified form of genetic arrhythmogenic disorder, named "Triadin KnockOut Syndrome" (TKOS). TKOS is associated with recessive mutations in the TRDN gene, encoding for TRIADIN, but the pathogenic mechanism underlying the malignant phenotype has yet to be completely defined. Moreover, patients with TKOS are often refractory to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34575879
DOI: 10.3390/ijms22189720
PMCID: PMC8471218

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