Article

Cardiomyocyte ploidy is dynamic during postnatal development and varies across genetic backgrounds

2022-09-17

Abstract excerpt

<h4>SUMMARY</h4> Somatic polyploidization, an adaptation by which cells increase their DNA content to support cell and organ growth, is observed in many mammalian cell types, including cardiomyocytes. Although polyploidization is beneficial in many contexts, progression to a polyploid state is often accompanied by a loss of proliferative capacity. Recent work suggests that heterogeneity in cardiomyocyte ploidy is...

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Literature Corpus work: 138ea231-2443-5955-b5de-0c482634b781
DOI: 10.1101/2022.09.15.508152

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